P87PIKAP

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    Phosphoinositide-3-kinase adapter protein of 87 kDa
    Identifiers
    Symbolp87PIKAP
    Alt. symbolsp84,PIK3R6
    NCBI gene146850
    HGNC27101
    OMIM611462
    UniProtQ5UE93
    Other data
    LocusChr. 17 p13.1
    Search for
    StructuresSwiss-model
    DomainsInterPro

    Within molecular and cell biology, p87PIKAP is a regulatory subunit of the type IB Phosphoinositide 3-Kinase p110γ that is highly expressed in the heart and is present in dendritic cells, macrophages, and neutrophils.[1]It is also referred to as p84 and p87.[2] Some studies have found P87PIKAP to have a role in carcinogenesis.[3]

    References

    [edit]
    1. ^ Voigt P, Dorner MB, Schaefer M (2006). "Characterization of p87PIKAP, a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B". The Journal of Biological Chemistry. 281 (15): 9977–86. doi:10.1074/jbc.M512502200. PMID 16476736.
    2. ^ Kurig B, Shymanets A, Bohnacker T, Prajwal, Brock C, Ahmadian MR, et al. (2009). "Ras is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110gamma". Proceedings of the National Academy of Sciences of the United States of America. 106 (48): 20312–7. Bibcode:2009PNAS..10620312K. doi:10.1073/pnas.0905506106. PMC 2787109. PMID 19906996.
    3. ^ Brazzatti, JA; et al. (2012). "Differential roles for the p101 and p84 regulatory subunits of PI3Kc in tumor growth and metastasis" (PDF). Oncogene. 31 (18): 2350–2361. doi:10.1038/onc.2011.414. PMID 21996737. S2CID 24708435.
    The context of the function of p87.


    Stub icon

    This protein-related article is a stub. You can help Wikipedia by expanding it.

    Retrieved from "https://en.wikipedia.org/w/index.php?title=P87PIKAP&oldid=1115911259"
      Phosphoinositide-3-kinase adapter protein of 87 kDa
      Identifiers
      Symbolp87PIKAP
      Alt. symbolsp84,PIK3R6
      NCBI gene146850
      HGNC27101
      OMIM611462
      UniProtQ5UE93
      Other data
      LocusChr. 17 p13.1
      Search for
      StructuresSwiss-model
      DomainsInterPro

      Within molecular and cell biology, p87PIKAP is a regulatory subunit of the type IB Phosphoinositide 3-Kinase p110γ that is highly expressed in the heart and is present in dendritic cells, macrophages, and neutrophils.[1]It is also referred to as p84 and p87.[2] Some studies have found P87PIKAP to have a role in carcinogenesis.[3]

      References

      1. ^ Voigt P, Dorner MB, Schaefer M (2006). "Characterization of p87PIKAP, a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B". The Journal of Biological Chemistry. 281 (15): 9977–86. doi:10.1074/jbc.M512502200. PMID 16476736.
      2. ^ Kurig B, Shymanets A, Bohnacker T, Prajwal, Brock C, Ahmadian MR, et al. (2009). "Ras is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110gamma". Proceedings of the National Academy of Sciences of the United States of America. 106 (48): 20312–7. Bibcode:2009PNAS..10620312K. doi:10.1073/pnas.0905506106. PMC 2787109. PMID 19906996.
      3. ^ Brazzatti, JA; et al. (2012). "Differential roles for the p101 and p84 regulatory subunits of PI3Kc in tumor growth and metastasis" (PDF). Oncogene. 31 (18): 2350–2361. doi:10.1038/onc.2011.414. PMID 21996737. S2CID 24708435.
      The context of the function of p87.


      Stub icon

      This protein-related article is a stub. You can help Wikipedia by expanding it.

      Retrieved from "https://en.wikipedia.org/w/index.php?title=P87PIKAP&oldid=1115911259"