エピジェネティクスの記事

Colonic epithelium from a mouse not undergoing colonic tumorigenesis (A), and a mouse that is undergoing colonic tumorigenesis (B). Cell nuclei are stained dark blue with hematoxylin (for nucleic acid) and immunostained brown for 8-oxo-dG. The level of 8-oxo-dG was graded in the nuclei of colonic crypt cells on a scale of 0-4. Mice not undergoing tumorigenesis had crypt 8-oxo-dG at levels 0 to 2 (panel A shows level 1) while mice progressing to colonic tumors had 8-oxo-dG in colonic crypts at levels 3 to 4 (panel B shows level 4) Tumorigenesis was induced by adding deoxycholate to the mouse diet to give a level of deoxycholate in the mouse colon similar to the level in the colon of humans on a high fat diet.[12] The images were made from original photomicrographs.

OGG1酸化ストレスからDNAを守る修復酵素の役割とがんとの関係

OGG18-オキソグアニンDNA修復塩基除去修復

続きを読む →

Structure of the base-excision repair enzyme uracil-DNA glycosylase. The uracil residue is shown in yellow.

DNAグリコシラーゼ塩基除去修復を担う酵素の仕組みと疾患への関与

DNAグリコシラーゼ塩基除去修復BERAPサイト

続きを読む →

DNA damage resulting in multiple broken chromosomes

DNA修復のメカニズムと生命維持における重要性

DNA修復ゲノム安定性DNA損傷がんリスク

続きを読む →