DNA修復の記事

The image demonstrates how ligase (yellow oval) catalyzes two DNA fragment strands. The ligase joins the two fragments of DNA to form a longer strand of DNA by "pasting" them together.

DNAリガーゼの仕組みと役割生命の設計図を繋ぎ合わせる分子の糊

DNAリガーゼホスホジエステル結合DNA複製DNA修復

続きを読む →

Colonic epithelium from a mouse not undergoing colonic tumorigenesis (A), and a mouse that is undergoing colonic tumorigenesis (B). Cell nuclei are stained dark blue with hematoxylin (for nucleic acid) and immunostained brown for 8-oxo-dG. The level of 8-oxo-dG was graded in the nuclei of colonic crypt cells on a scale of 0-4. Mice not undergoing tumorigenesis had crypt 8-oxo-dG at levels 0 to 2 (panel A shows level 1) while mice progressing to colonic tumors had 8-oxo-dG in colonic crypts at levels 3 to 4 (panel B shows level 4) Tumorigenesis was induced by adding deoxycholate to the mouse diet to give a level of deoxycholate in the mouse colon similar to the level in the colon of humans on a high fat diet.[12] The images were made from original photomicrographs.

OGG1酸化ストレスからDNAを守る修復酵素の役割とがんとの関係

OGG18-オキソグアニンDNA修復塩基除去修復

続きを読む →

トーマス・リンダール博士とDNA修復メカニズムの解明

トーマス・リンダールDNA修復ノーベル化学賞DNAリガーゼ

続きを読む →

Neoplastic tumor of the cheek skin, here a benign neoplasm of the sweat glands called hidradenoma, which is not solid but is fluid-filled

新生物（ネオプラズム）のメカニズム良性腫瘍から悪性腫瘍への進展

新生物腫瘍良性腫瘍悪性腫瘍

続きを読む →

DNA damage resulting in multiple broken chromosomes

DNA修復のメカニズムと生命維持における重要性

DNA修復ゲノム安定性DNA損傷がんリスク

続きを読む →