Finrozole

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    Finrozole
    Names
    Preferred IUPAC name
    4-[(1R,2S)-3-(4-Fluorophenyl)-2-hydroxy-1-(1H-1,2,4-triazol-1-yl)propyl]benzonitrile
    Identifiers
    3D model (JSmol)
    ChEMBL
    ChemSpider
    ECHA InfoCard100.219.051 Edit this at Wikidata
    UNII
    • InChI=1S/C18H15FN4O/c19-16-7-3-13(4-8-16)9-17(24)18(23-12-21-11-22-23)15-5-1-14(10-20)2-6-15/h1-8,11-12,17-18,24H,9H2/t17-,18+/m0/s1
      Key: SLJZVZKQYSKYNV-ZWKOTPCHSA-N
    • C1=CC(=CC=C1C[C@@H]([C@@H](C2=CC=C(C=C2)C#N)N3C=NC=N3)O)F
    Pharmacology
    QG03XX90 (WHO)
    Legal status
    Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

    Finrozole is an aromatase (CYP19A1) inhibitor.[2]

    Finrozole was authorized for veterinary use in the European Union in April 2025.[1]

    Medical uses

    [edit]

    Finrozole is indicated to shorten the pro-oestrus and oestrus period, reduce clinical signs of heat and reduce the risk of pregnancy.[1]

    References

    [edit]
    1. ^ a b c "Prevestrus vet PI". Union Register of medicinal products. 25 April 2025. Retrieved 3 May 2025.
    2. ^ Huuskonen, P; Myllynen, P; Storvik, M; Pasanen, M (2013). "The effects of aflatoxin B1 on transporters and steroid metabolizing enzymes in JEG-3 cells". Toxicology Letters. 218 (3): 200–6. doi:10.1016/j.toxlet.2013.01.015. PMID 23402939.


    Stub icon

    This antineoplastic or immunomodulatory drug article is a stub. You can help Wikipedia by expanding it.

    Retrieved from "https://en.wikipedia.org/w/index.php?title=Finrozole&oldid=1330278844"
      Finrozole
      Names
      Preferred IUPAC name
      4-[(1R,2S)-3-(4-Fluorophenyl)-2-hydroxy-1-(1H-1,2,4-triazol-1-yl)propyl]benzonitrile
      Identifiers
      • 160146-17-8 checkY
      3D model (JSmol)
      • Interactive image
      ChEMBL
      • ChEMBL2218882
      ChemSpider
      • 5293483
      ECHA InfoCard100.219.051
      • 6918277
      UNII
      • 40028KHQ6B checkY
      • DTXSID90166806
      • InChI=1S/C18H15FN4O/c19-16-7-3-13(4-8-16)9-17(24)18(23-12-21-11-22-23)15-5-1-14(10-20)2-6-15/h1-8,11-12,17-18,24H,9H2/t17-,18+/m0/s1
        Key: SLJZVZKQYSKYNV-ZWKOTPCHSA-N
      • C1=CC(=CC=C1C[C@@H]([C@@H](C2=CC=C(C=C2)C#N)N3C=NC=N3)O)F
      Pharmacology
      QG03XX90 (WHO)
      Legal status
      • EU: Rx-only[1]
      Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

      Finrozole is an aromatase (CYP19A1) inhibitor.[2]

      Finrozole was authorized for veterinary use in the European Union in April 2025.[1]

      Medical uses

      Finrozole is indicated to shorten the pro-oestrus and oestrus period, reduce clinical signs of heat and reduce the risk of pregnancy.[1]

      References

      1. ^ a b c "Prevestrus vet PI". Union Register of medicinal products. 25 April 2025. Retrieved 3 May 2025.
      2. ^ Huuskonen, P; Myllynen, P; Storvik, M; Pasanen, M (2013). "The effects of aflatoxin B1 on transporters and steroid metabolizing enzymes in JEG-3 cells". Toxicology Letters. 218 (3): 200–6. doi:10.1016/j.toxlet.2013.01.015. PMID 23402939.


      Stub icon

      This antineoplastic or immunomodulatory drug article is a stub. You can help Wikipedia by expanding it.

      Retrieved from "https://en.wikipedia.org/w/index.php?title=Finrozole&oldid=1330278844"